Our new preprint is now available on bioRxiv! This study highlights the promise of rapid phenotypic RNA-based tests for antimicrobial resistance, however also emphasizes the importance of controlling for population structure. Check it out here!
(DE)CONSTRUCTING BAD BUGS!
The making of a bad bug! Finally, after 5 days of selection and nursing these little guys along I am seeing a HUGE increase in resistance in my gonococcal cell lines (causal agent of gonorrhea). Though is may seem like a bad idea to evolve bacterial resistance to antibiotics in the lab, we are trying to understand how these bacteria gain resistance mutations. For example, can they gain resistance mutations alone and be totally fine and happy or do they need other mutations that are enabling or compensatory first. Ultimately, this may help us target new pathways for antibiotic development or in discovering bacterial populations that are more likely to evolve resistance to certain drugs than others which may impact prescription practices in certain areas.
Lecture at RIT
I am very grateful to have been invited to RIT to talk about my work on antimicrobial resistance within the Neisseria! I was able to spend a few days learning about the School of Life Sciences, and the exciting research conducted by faculty and students in the department. Their innovative approaches to experiential hands-on learning in the classroom were awesome to learn about, and something that I would like to model in my own future teaching!
I feel so honored to have been selected to participate in the inaugural UR Stars Program at the University of Rochester! It was wonderful connecting with old friends and meeting new ones; while learning about opportunities at the university and the history of Rochester. Special thanks to the UR Faculty Development and Diversity Office for hosting this program.
FDA PLAN TO COMBAT RESISTANCE
I am very excited to hear about the FDA's new and ongoing activities to support good antimicrobial stewardship in human medicine and animal agricultural settings, and their support of antibiotic research and development. Should be an insightful panel discussion! Tune in TODAY! (https://www.pewtrusts.org/about/events/2018/fda-unveils-plan-to-combat-antibiotic-resistance) #FDAatPew
What a great day at the DATA-POWERED STRATEGIES TO COUNTERACT ANTIBIOTIC RESISTANCE #dataAMR18 conference hosted at the Harvard Medical School! There is so much exciting work being done to fight resistance from the development of paper-based diagnostics that can detect single-SNP variants, to high-throughput screens for novel antimicrobial compounds, to real-time genome-sequencing and resistance prediction. Development of these diverse arms of research, and complementary implementation of them in the future, will be critical to stemming the emergence and spread of resistance!
The Grad lab is back from our annual retreat, this time in Shrewsbury VT! Fresh air, a mountain hike, and discovering the "ice rocks" of the area was truly a spectacular experience. What a great group of people to be a part of. Now back to the lab!
Crista Wadsworth is an Assistant Professor at RIT. Current projects focus on the resistome within commensal Neisseria.