WADSWORTH LAB @ RIT
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New preprint: Neisseria resistome

7/31/2020

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A big congratulations to RIT students Michael Foire and Jordan Raisman on their new preprint (https://www.biorxiv.org/content/10.1101/2020.07.30.228593v1)! This work characterizes resistance across the commensal Neisseria, which are known sources of resistance for their pathogenic cousin, Neisseria gonorrhoeae. Using both MIC testing and whole genome sequencing, several resistance-encoding mutations are nominated in non-pathogenic species. 
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New Manuscript: Rapid inference of antibiotic resistance and susceptibility by genomic neighbour typing

2/28/2020

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Congratulations to collaborators on the publication of "Rapid inference of antibiotic resistance and susceptibility by genomic neighbor typing" in Nature Microbiology! Here we present a new method for identifying resistant bacteria within minutes (<10 min), using real-time Nanopore sequencing and phenotypic inference from near phylogenetic neighbors. One step closer to point of care resistance diagnostics which will enable tailored therapies for individual patients! Check it out here: https://doi.org/10.1038/s41564-019-0656-6.
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The Wadsworth Lab @ RIT is Taking Shape!

1/10/2020

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The lab is finally coming together, and I am so excited to get started with my incoming students this semester. I can not wait to see the paths we will take towards discovery, the unexpected challenges and creative solutions used to overcome these obstacles, and the team that we will build. Here's to the future, watch out gonococcus!
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Please join me for my seminar tomorrow

10/15/2019

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New Faculty Orientation @ RIT

8/19/2019

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Feeling excited to get started here at RIT after the New Faculty Orientation! #RITscience #RITGSOLS
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New Preprint: Using Linkage Patterns to Understand the Selective Pressures That Bacteria Face

5/15/2019

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The ecological pressures that bacteria face can be hard to determine, however selection leaves clear signatures within the genome. In our recent preprint, spearheaded by Dr. Brian Arnold, we look at patterns of linkage to nominate the selective pressures faced by the recombining bacterial pathogen Neisseria gonorrhoeae. Clear signatures emerge, suggestive of a large role of adaptive interspecies admixture and/or balancing selection (perhaps due to the existence of distinct ecological niches or colonization sites) in shaping population level diversity in this species. Congratulations to all involved!
See our preprint here: 
https://www.biorxiv.org/content/10.1101/634147v1
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New Preprint: The Genomic Basis of Circannual Timing in the European Corn Borer Moth

5/15/2019

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Our study, lead by Dr. Genevieve M. Kozak, was recently published as a preprint on bioRxiv. Congratulations to all involved! This work highlights that the genetic basis of complex traits like seasonal timing and resultant ecological speciation, can be controlled by a relatively simple genetic basis. Here, we find that two genes involved in the circadian clock pathway underlie this trait in the European Corn Borer moth, a major agricultural pest of corn in North America and Europe. Ultimately, describing the genetic basis of seasonality may help us better predict the extinction or survival outcomes due to climate change for particular species, and also gain a better understanding of range expansions in insect systems.
​See our preprint here: 
https://www.biorxiv.org/content/10.1101/633362v1
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Wadsworth Lab @ RIT

2/7/2019

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I will officially be starting my lab at the Rochester Institute of Technology in the School of Life Sciences fall 2019! Research in the lab will focus on the potential for commensal Neisseria to serve as sources of resistance for pathogens. If you have an interest in joining the lab please feel free to contact me!
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PHENOTYPIC DIAGNOSTICS FOR RESISTANCE

2/5/2019

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Our new preprint is now available on bioRxiv! This study highlights the promise of rapid phenotypic RNA-based ​tests for antimicrobial resistance, however also emphasizes the importance of controlling for population structure. Check it out here!
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(DE)CONSTRUCTING BAD BUGS!

2/5/2019

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The making of a bad bug! Finally, after 5 days of selection and nursing these little guys along I am seeing a HUGE increase in resistance in my gonococcal cell lines (causal agent of gonorrhea). Though is may seem like a bad idea to evolve bacterial resistance to antibiotics in the lab, we are trying to understand how these bacteria gain resistance mutations. For example, can they gain resistance mutations alone and be totally fine and happy or do they need other mutations that are enabling or compensatory first. Ultimately, this may help us target new pathways for antibiotic development or in discovering bacterial populations that are more likely to evolve resistance to certain drugs than others which may impact prescription practices in certain areas. ​
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    Crista Wadsworth is an Assistant Professor at RIT. Current projects focus on the resistome within commensal Neisseria.

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